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Collagenous colitis associated with lansoprazole.

Gilbert M Wilcox¹, Anthony Mattia

¹Department of Gastroenterology, Maine Medical Center, Portland, Maine, USA.

Journal of Clinical Gastroenterology

|January 10, 2002

Summary

This case report suggests lansoprazole may cause collagenous colitis, a diarrheal illness. Symptoms resolved upon drug cessation and reappeared with re-exposure, indicating a potential drug-induced condition.

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Area of Science:

Gastroenterology
Pharmacology
Pathology

Background:

Collagenous colitis is a diarrheal illness with an unknown etiology.
This report details a case of collagenous colitis potentially linked to lansoprazole exposure.

Observation:

A patient presented with symptoms and histopathologic findings consistent with collagenous colitis.
These clinical and pathological changes occurred during treatment with proton pump inhibitors, specifically lansoprazole and omeprazole.

Findings:

Diarrheal symptoms and histopathologic abnormalities in the patient resolved after discontinuing lansoprazole.
Upon re-exposure to lansoprazole, the patient's symptoms and pathological findings recurred, strongly suggesting a causal relationship.

Implications:

Related Experiment Videos

The findings suggest a potential association between lansoprazole use and the development of collagenous colitis.
This case highlights the importance of considering drug-induced causes in patients presenting with collagenous colitis or lymphocytic colitis.