Related Experiment Videos
Acute renal failure in patients with rhabdomyolysis
Wladyslaw Sułowicz1, Boguslaw Walatek, Antoni Sydor
1Department of Nephrology, Jagiellonian University Hospital, Cracow, Poland.
Background:
Rhabdomyolysis is a relatively rare, not always diagnosed cause of acute renal failure (ARF). This fact motivated us to present the results of ARF treatment in the course of this polyetiological clinical syndrome.
Material/Methods:
The analysis was performed on 84 patients (6 F, 78 M) ranging in age from 18 to 82 years (mean 46.5), in whom rhabdomyolysis was diagnosed based on clinical manifestation and laboratory test results (CPK, GTP, GOT, LDH).
Results:
The most frequent cause of rhabdomyolysis was alcoholic intoxication (41 patients), often accompanied by hypothermia (15 patients) or trauma (30 patients). Isolated trauma was found in 30 patients, epileptic seizure in 5, and physical exercise in 1 case. In 17 patients, besides alcohol consumption, trauma or epileptic seizure, the use of tranquilizers, anticonvulsants, or narcotic drugs was additionally noted. 78 patients developed ARF requiring dialysis therapy; 49 patients recovered, 5 required maintenance dialysis, and 30 died.
Conclusions:
During the initial phase of ARF in the course of rhabdomyolysis dynamic increases in serum urea and creatinine were observed, as well as a tendency to hyperkalemia. The treatment results and mortality rate in our study group were primarily influenced by the patients' general condition at admission, as well as the extent of organ damage caused by the primary etiological factor. Favorable treatment results were obtained especially in those patients who were hospitalized in a nephrological center, while the worst outcomes were noted in those patients dialyzed in intensive care units, most with multiple trauma.
Insights
Rhabdomyolysis can cause acute renal failure (ARF). Early hospitalization in a nephrology center improved outcomes for patients with rhabdomyolysis-induced ARF, while intensive care unit treatment led to worse results.
Area of Science:
- Nephrology
- Toxicology
- Internal Medicine
Background:
- Rhabdomyolysis is an underdiagnosed cause of acute renal failure (ARF).
- This study examines ARF treatment within the context of rhabdomyolysis.
Purpose of the Study:
- To analyze the treatment outcomes of acute renal failure (ARF) in patients with rhabdomyolysis.
- To identify factors influencing treatment success and mortality rates.
Main Methods:
- Retrospective analysis of 84 patients diagnosed with rhabdomyolysis.
- Evaluation of clinical manifestations and laboratory results (CPK, GTP, GOT, LDH).
Main Results:
- Alcoholic intoxication was the most common cause of rhabdomyolysis (41 patients).
- 78 patients developed ARF requiring dialysis; 49 recovered, 5 needed maintenance dialysis, and 30 died.
- Trauma and substance use were frequent co-factors.
Conclusions:
- Dynamic increases in serum urea, creatinine, and hyperkalemia were observed during ARF.
- Patient's condition at admission and extent of organ damage significantly impacted outcomes.
- Hospitalization in a nephrological center correlated with better outcomes compared to intensive care units.