Essential arginyl residues in thymidylate synthetase from amethopterin-resistant Lactobacillus casei

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

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Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

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Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

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Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

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The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

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Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

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Related Experiment Videos

Essential arginyl residues in thymidylate synthetase from amethopterin-resistant Lactobacillus casei

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.

The Photocycle of the Red Light-Sensitive Plant-like Cryptochrome CryP from Phaeodactylum tricornutum.

Chemical Pathway-Dependent Structural Reorganization at a Hinge Microenvironment in the AcrA Adaptor Protein.

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions.

Recognition of Single-Strand-Duplex Junctions in RNA Using Peptide Nucleic Acids That Form Watson-Crick and Hoogsteen Hydrogen Bond.

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

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Systematic mining and characterization of metal transporter families regulating zinc homeostasis provide insights into metal homeostasis in Camellia sinensis.

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The transcription factor CsART1 activates the aluminum transporter CsALS3s to promote the absorption and tolerance of aluminum in tea plants.

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Related Experiment Videos

Essential arginyl residues in thymidylate synthetase from amethopterin-resistant Lactobacillus casei

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