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Transplantation of cultured human neural progenitor cells into rat brain: migration and differentiation
M A Aleksandrova1, R A Poltavtseva, M V Marei
1N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow.
Abstract:
We studied the fate in vitro cultured human stem/progenitor cells after transplantation into rat brain. The cells from human fetuses at 8-12 weeks' gestation were cultured in vitro for 14 days and transplanted into the brain of 10-day-old and adult rats. Microscopic examination showed that human stem/progenitor cells migrated into various regions of rat brain. Immunohistochemical assay demonstrated that some cells differentiated into astrocytes and neurons, while others retained the embryonic phenotype.
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