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[Telomerase activity of common malignant tumors]
1Department of Medical Genetics, Shandong Medical University, Jinan 250012, China.
Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|January 11, 2002
Abstract
Objective:
To study the usefulness of detection of telomerase activity in the diagnosis of malignant tumors.
Methods:
Modified telomeric repeat amplification protocol (TRAP) was employed to examine telomerase activity in 283 malignant tumor tissues, 42 adjacent tissues and 61 benign tumor tissues.
Results:
Of the 283 malignant tumors and 42 adjacent tissues, telomerase was positive in 264 (93.3%) and 11 (26.1%), respectively. Only 4 of the 62 (6.6%) benign tumors were telomerase positive.
Conclusion:
Telomerase activity may be used as tumor marker in the diagnosis of malignant tumors.