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Updated: Aug 19, 2026
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
Published on: June 7, 2016
[Expression of nm23 in breast cancer: correlation with distant metastasis and prognosis]
1Breast Department, Tianjin Cancer Institute & Hospital, Tianjin Medical University, Tianjing 300060, China.
Objective:
To investigate the relationship between expression of nm23 gene and distant metastasis and prognosis in breast cancer.
Methods:
To detect nm23 protein expression in 101 patients with breast cancer by means of immunohistochemistry and nm23 mRNA expression in 68 patients with breast cancer by RT-PCR.
Results:
Expression of nm23 gene was inversely correlated with distant metastasis and lymph node metastasis. Among 9 patients with negative node but with distant metastasis, 7 had low expression of nm23. In 29 patients with positive nodes but without distant metastasis, 24 had high expression of nm23, while 6 of 6 patients with positive nodes and distant metastasis expressed high levels of nm23 mRNA.
Conclusion:
Expression of nm23 gene, tumor size and status of axillary lymph node are independent prognostic indicators to breast cancer prognosis.
