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[Placental expression of epidermal growth factor receptor in pregnancy induced hypertension]
1Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Objective:
To clarify the expression of epidermal growth factor receptor (EGFR) in placenta from women with pregnancy induced hypertension (PIH).
Methods:
EGFR of placenta was determined by immunohistological method and compared between normal pregnancies (34 cases) and pregnancies accompanied by PIH (30 cases).
Results:
Positive immunostain of EGFR was located on cytoplasm, and membrane of syncytiotrophoblast and a small part of cytotrophoblast. Compared with that of normal pregnancy, the expression of EGFR in placenta from pregnancies complicated with PIH decreased significantly (P < 0.05). No significant differences of EGFR expression in placenta were found among women with mild, moderate and severe PIH (P > 0.5). No significant correlation was found between expression of EGFR and neonatal birthweight, placental weight (P > 0.01, for both).
Conclusion:
Decreased expression of placental EGFR was found in women with PIH, and that may play a role in the pathogenesis of PIH.