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[Clinical study on tangshen mixture in treating diabetic nephropathy]
Summary
Tangshen Mixture (TSM) significantly improved outcomes for diabetic nephropathy (DN) patients by reducing proteinuria and oxidative stress. The herbal treatment also improved hypercoagulative status, offering a potential therapeutic option for DN management.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetic nephropathy (DN) is a major complication of diabetes, characterized by proteinuria, hypercoagulability, and oxidative stress.
- Current treatments for DN have limitations, highlighting the need for novel therapeutic strategies.
Purpose of the Study:
- To evaluate the efficacy of Tangshen Mixture (TSM) in managing key indicators of DN.
- To assess TSM's impact on serum glucose, proteinuria, coagulation status, and oxidative injury in DN patients.
Main Methods:
- A randomized controlled trial involving 93 DN patients, divided into TSM + insulin and insulin-only groups.
- Key biomarkers including fasting blood glucose (FBG), postprandial blood glucose (PBG), 24-hour urinary albumin (24 h-pro), endothelin (ET), alpha-granule membrane glycoprotein-140 (GMP-140), erythrocyte superoxide dismutase (ESOD), and lipid peroxidase (LPO) were measured before and after treatment.
Main Results:
- The TSM group showed significant reductions in ET, GMP-140, LPO, and 24 h-pro compared to the control group (P < 0.01, P < 0.05).
- ESOD levels significantly increased in the TSM group (P < 0.05), indicating reduced oxidative stress.
- No significant changes were observed in the control group after treatment.
Conclusions:
- TSM effectively improves hypercoagulative status in DN patients.
- TSM alleviates renal free radical disturbances, suggesting a protective effect against oxidative injury.
- TSM significantly reduces urinary protein loss, a key marker of kidney damage in DN.