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[Apoptosis inducing effect of meisoindigo on K562 cells]
1Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin (300020).
Objective:
To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.
Methods:
Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to observe the effect of meisoindigo on K562 cells.
Results:
Meisoindigo can inhibit the proliferation and induce the apoptosis of K562 cells.
Conclusion:
The therapeutic mechanism of meisoindigo in treating CML may be related with its proliferation inhibiting and apoptosis inducing effect in CML cells.