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[Effect of xuefu zhuyu decoction on function of platelet and endothelial cell]
Objective:
To explore the effect of Xuefu Zhuyu Decoction (XFZYD) on function of platelet and endothelial cell.
Methods:
Through incubation of XFZYD, in different concentration, with platelet and human umbilical vein endothelial cell, the platelet membrane glycoprotein II b/III a complex and thrombomoduline (TM) of human umbilical vein endothelial cell were determined by radioimmunoassay.
Results:
XFZYD in 40 mg/ml or 80 mg/ml could obviously inhibit the adenosine diphosphate induced glycoprotein II b/III a molecular expression, as compared with the control group, the difference was significant (P < 0.05, P < 0.01), but it did not influence the TM level significantly.
Conclusion:
XFZYD could inhibit the adenosine diphosphate induced activation of platelet through blocking the exposure of glycoprotein II b/III a complex.