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[Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells]
1Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021).
Abstract
Objective:
To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL-60 cells.
Methods:
Effects of ursolic acid on the growth and apoptosis were evaluated by MTT assay, DNA gel electrophoresis and morphology observation respectively.
Results:
The IC50 value of ursolic acid for HL-60 cells was found to be 8.26 mumol/L and 10-50 mumol/L of ursolic acid could induce apoptosis of HL-60 cells expressed to ursolic acid for 1 day.
Conclusion:
Ursolic acid can markedly inhibit HL-60 cells as well as induction of cells apoptosis.