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Updated: Sep 15, 2026
Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
Published on: October 13, 2018
[Contrast study on effect of shenkang injection and benazepril on human glomerular mesangial extracellular matrix]
Objective:
To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM).
Methods:
Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro.
Results:
SKI could inhibit the fibronetin, laminin, and type IV collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit the fibronetin and type IV collagen of ECM but was weaker in intensity.
Conclusion:
The effect of SKI was superior to Benazepril in inhibiting ECM.
