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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
[Expression of endometrial leukaemia inhibitory factor gene in patients with unexplained infertility]
1Department of Obstetrics and Gynecology, Sichuan Provincal People's Hospital, Chengdu 610072, China.
Objective:
To investigate the expression of endometrial leukaemia inhibitory factor(LIF) gene in patients with unexplained infertility.
Methods:
By a quantitative reverse transcription-polymerase chain reaction (RT-PCR), the expression of LIF gene on endometrium during mid-luteal phase was detected in 35 unexplained infertility (infertility group) cases and 20 infertile cases due to tubal obstruction or male factor (control group).
Results:
The level of LIF mRNA expression on endometrium during mid-luteal phase in infertility group was 0.448 +/- 0.239, significantly lower than those in the control group (1.093 +/- 0.761, P < 0.01).
Conclusions:
Our findings suggested LIF might play an important role in the process of implantation. The decreased expression of LIF gene might be one of the major causes of unexplained infertility.
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