Related Experiment Video

Updated: Oct 3, 2026

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
11:08

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling

Published on: February 5, 2018

Synthesis and potent anti-HIV activity of L-3'-fluoro-2',3'-unsaturated cytidine

G Gumina1, R F Schinazi, C K Chu

  • 1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602, USA.

Organic Letters
|January 11, 2002
PubMed

Abstract:

L-2',3'-Didehydro-2',3'-dideoxy-3'-fluorocytidine (L-3'-Fd4C), a novel potent anti-HIV agent (EC(50) 0.03 microM in PBM cells), has been synthesized from L-xylose in 14 steps. [reaction: see text]

More Related Videos

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
10:50

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
13:47

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Published on: June 23, 2011

Related Experiment Videos

Last Updated: Oct 3, 2026

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
11:08

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling

Published on: February 5, 2018

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
10:50

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
13:47

Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Published on: June 23, 2011

Related Concept Videos

Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...

Articles linked to this work by shared authors, journal, and citation graph.

Prediction in routine care: a naturalistic comparison of clinicians and a machine learning model for patients receiving treatment for generalised anxiety disorder.

Psychotherapy research : journal of the Society for Psychotherapy Research·2026

HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.

HIV medicine·2015

Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance.

Current medicinal chemistry·2015

All-oral, interferon-free treatment for chronic hepatitis C: cost-effectiveness analyses.

Journal of viral hepatitis·2013

Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses.

Journal of virology·2013

Laboratory safety considerations.

Methods in molecular medicine·2011

Solid-Phase Synthesis of Enteropeptin A Analogues.

Organic letters·2026

Pd-Catalyzed Freon-Enabled Aminocarbonylation of Aryl Iodides.

Organic letters·2026

Criegee Intermediate-Enabled Decarboxylative C(sp3)-C(sp3) Cross-Coupling of α,β-Unsaturated Esters with Cyclic Acetals.

Organic letters·2026

Scaffold Hopping of Pyrimidines into 2-Acylpyrroles.

Organic letters·2026

Multidimensional Involvement of Tris(4-methoxyphenyl)amine in Electrolytic Sulfonylation of Alkenes.

Organic letters·2026

Photocatalytic Scaffold Hopping of Cyclobutanols to Cyclopentanols via Single-Carbon Insertion into C-C σ-Bonds.

Organic letters·2026

Apoptosis-inducing potential of the hexane fraction of Cassia fistula L. against MCF-7 cells via apoptosis signaling pathways.

Biochemistry and biophysics reports·2026

A novel 1,3-diazetidine-2-thione derivative with antibacterial and immunomodulatory activity against Proteus mirabilis: in vitro, in vivo, ADMET, docking, and molecular dynamics evaluation.

In silico pharmacology·2026

DancE: A DNA-Activated Bacterial cGAS-like Enzyme in Antiphage Immune Defense.

bioRxiv : the preprint server for biology·2026

Reversible, Orally Bioavailable Small-Molecule Inhibitors Occupy the Substrate Tunnel of the Thioesterase Domain of Fatty Acid Synthase.

bioRxiv : the preprint server for biology·2026

Peptides derived from TsAP-2 exhibit potential antifungal activity against Candida species and promote non-infected wound healing both in vitro and in vivo.

Biochimie·2026

Dysoverines G-K from the rhizome of Dysosma tonkinense and their cytotoxic activity.

Fitoterapia·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us