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Synthesis and potent anti-HIV activity of L-3'-fluoro-2',3'-unsaturated cytidine

G Gumina1, R F Schinazi, C K Chu

  • 1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602, USA.

Organic Letters
|January 11, 2002
PubMed

Abstract:

L-2',3'-Didehydro-2',3'-dideoxy-3'-fluorocytidine (L-3'-Fd4C), a novel potent anti-HIV agent (EC(50) 0.03 microM in PBM cells), has been synthesized from L-xylose in 14 steps. [reaction: see text]

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