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Related Experiment Videos

Naltrexone for alcohol dependence: a randomized controlled trial.

P L Morris1, M Hopwood, G Whelan

  • 1The Australian National Centre for War-related PTSD at the Austin Repatriation Medical Centre, Heidelberg, Melbourne, Australia.

Addiction (Abingdon, England)
|January 11, 2002
PubMed
Summary
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Naltrexone, an opioid antagonist, effectively reduced relapse to drinking in alcohol-dependent men over 12 weeks. This medication was well-tolerated and showed promise in limited psychosocial treatment settings.

Area of Science:

  • Clinical Medicine
  • Pharmacology
  • Addiction Psychiatry

Background:

  • Alcohol dependence is a significant public health issue.
  • Opioid antagonists like naltrexone have shown potential in treating substance use disorders.
  • Limited psychosocial support may impact treatment efficacy for alcohol dependence.

Purpose of the Study:

  • To evaluate the efficacy of naltrexone in preventing relapse to drinking among alcohol-dependent men.
  • To assess the safety and tolerability of naltrexone in this patient population.

Main Methods:

  • A 12-week randomized, placebo-controlled clinical trial.
  • Participants were male subjects with alcohol dependence.
  • Naltrexone (50 mg daily) or placebo was administered, with weekly education support group attendance.

Related Experiment Videos

Main Results:

  • Fewer naltrexone-treated subjects relapsed compared to placebo (p = 0.001) in the intention-to-treat analysis.
  • Naltrexone significantly reduced alcohol consumption among completers of the 12-week trial.
  • Naltrexone was well-tolerated with minimal adverse experiences.

Conclusions:

  • Naltrexone is effective in preventing relapse to drinking in alcohol-dependent men, particularly within limited psychosocial treatment contexts.
  • Further research is warranted to determine optimal treatment durations for sustained effects.
  • Naltrexone represents a viable pharmacological option for alcohol dependence management.