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[Cerebral vasoreactivity and functional response in stroke: a study with functional MR].
1Department of Clinical Neuroscience; FMRIB Centre. John Radcliffe Hospital., Oxford, OX3 9DU, Reino Unido. rpineiro@sghms.ac.uk
Revista De Neurologia
|January 11, 2002
Summary
Patients with lacunar infarcts showed altered temporal BOLD signal responses but similar activation patterns compared to controls. This suggests potential vascular changes impacting hemodynamic responses post-stroke, requiring cautious interpretation in clinical settings.
Area of Science:
- Neuroimaging
- Vascular Neurology
- Functional Magnetic Resonance Imaging (fMRI)
Background:
- Lacunar infarcts are linked to microvascular changes affecting cerebral function and adaptation.
- Blood-oxygen-level-dependent (BOLD) contrast in fMRI reflects hemodynamic changes, useful for studying brain activation patterns.
Purpose of the Study:
- To compare the temporal dynamics of BOLD signals and activation distribution between stroke patients without functional sequelae and healthy controls.
- To investigate the impact of lacunar infarcts on brain activation patterns using 3T fMRI.
Main Methods:
- Functional magnetic resonance imaging (fMRI) at 3 Tesla was employed.
- Comparison of BOLD signal temporal behavior and activation distribution between a stroke patient group and a control group.
Main Results:
- No statistically significant difference in the number of activated voxels or activation patterns between groups.
- The stroke group exhibited an 85% slower BOLD response in the sensorimotor area (p<0.01).
Conclusions:
- Similar activation patterns suggest minimal adaptive changes in this stroke cohort.
- The altered temporal BOLD response in stroke patients may indicate underlying vascular-related hemodynamic alterations.
- Findings necessitate caution when interpreting fMRI activation in individuals with vascular pathology.