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Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
Published on: November 8, 2014
[The problem of histological nomenclature and classification of carcinogenesis stages in the breast]
1Russian Academy of Further Medical Training, Moscow.
Abstract:
Objective diagnostic criteria for carcinogenesis staging and classification are suggested on the basis of a ploidometric investigation of 15,000 nuclei of cells of lobular and ductal epithelial neoplasms of the breast. Differential diagnosis is to apply to the following stages of mammary carcinogenesis: (a) signs of epithelial hyperplasia (/0) and intraepithelial neoplasia stage I (benign stages--/1); (b) intraepithelial neoplasia stage II (border-line stages--/2); (c) infiltrating carcinoma with or without metastases (malignant stages--/3).
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