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Related Experiment Video

Updated: Jul 26, 2026

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment

Published on: February 22, 2017

Ciguatera poisoning: a global issue with common management problems.

J Y Ting¹, A F Brown

¹Department of Emergency Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine

|January 12, 2002

Summary

Ciguatera poisoning, a foodborne illness from contaminated fish, causes debilitating symptoms and is increasingly seen in non-endemic areas. Intravenous mannitol effectively treated four tourists with ciguatera poisoning.

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Area of Science:

Toxicology
Foodborne Illness
Public Health

Background:

Ciguatera poisoning is a global foodborne illness caused by consuming fish contaminated with ciguatoxins.
It is endemic in tropical/subtropical regions but increasingly reported in temperate areas due to travel and fish importation.
Delayed diagnosis in developed countries poses a significant public health threat, with symptoms mimicking other neurological and constitutional disorders.

Observation:

A case series of four adult tourists who consumed contaminated fish in Vanuatu developed ciguatera poisoning.
All four patients responded favorably to intravenous mannitol treatment.
A fifth patient with similar initial symptoms was diagnosed with staphylococcal endocarditis and sepsis, highlighting diagnostic challenges.

Findings:

Ciguatera poisoning presents with a complex mix of gastrointestinal, neurocutaneous, and constitutional symptoms.
Intravenous mannitol showed efficacy in treating ciguatera poisoning in the observed cases.
Differential diagnosis is crucial, as symptoms can overlap with other conditions like sepsis, paralytic shellfish poisoning, and neurotoxic shellfish poisoning.

Implications:

Ciguatera poisoning requires increased awareness and diagnostic vigilance, especially in non-endemic regions.
Effective treatment options like intravenous mannitol should be considered for managing ciguatera poisoning.
Further research into ciguatera pathophysiology and epidemiology is needed to improve public health strategies and patient outcomes.