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Role of heparan sulfate in fibroblast growth factor signalling: a structural view
1Department of Biochemistry, University of Cambridge, UK. luca@cryst.bioc.cam.ac.uk
Current Opinion in Structural Biology
|January 12, 2002
Abstract:
Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to different models for receptor dimerisation.