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AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy
M Babincová1, P Cicmanec, V Altanerová
1Department of Biophysics and Chemical Physics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, Slovakia. babincova@fmph.uniba.sk
Bioelectrochemistry (Amsterdam, Netherlands)
|January 12, 2002
Abstract:
Large unilamellar magnetoliposomes (MLs) with encapsulated doxorubicin (DOX) (anticancer drug) were prepared by reverse-phase evaporation. They were exposed to an alternating magnetic field with a frequency of 3.5 MHz and an induction of 1.5 mT produced in three-turn pancake coil. The results showed that magnetoliposomes could be specifically heated to 42 degrees C (phase transition temperature of a used lipid) in a few minutes and during this, the encapsulated doxorubicin is massively released.