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Fluorescence studies on PAMAM dendrimers interactions with bovine serum albumin
1Department of General Biophysics, University of Łódz, Banacha 12/16, 90-237 Łódz, Poland. aklajn@biol.uni.lodz.pl
Bioelectrochemistry (Amsterdam, Netherlands)
|January 12, 2002
Abstract:
Polyamidoamine (PAMAM) dendrimers (generation 3.5 and 4) interaction with bovine serum albumin (BSA) was studied. The intensity of intrinsic fluorescence of two tryptophan residues and a shift in wavelength of their emission maxima were chosen as indicators of protein conformational changes. It is shown that the generation 4 has a greater impact on spectral properties of serum albumin than generation 3.5.