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Related Experiment Videos

Turner's syndrome: a paediatric perspective.

T C Sas1, S M de Muinck Keizer-Schrama,

  • 1Department of Paediatrics, Division of Endocrinology, Sophia Children's Hospital/University Hospital, Dr. Molewaterplein 40, NL-3015 GL Rotterdam, The Netherlands. sas@alkg.azr.nl

Hormone Research
|January 12, 2002
PubMed
Summary

Early growth hormone (GH) treatment for girls with Turner syndrome normalizes adult height. Combining GH with low-dose estrogens for puberty induction at age 12 is safe and effective.

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Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Growth Disorders

Background:

  • Turner syndrome significantly impacts girls' health, causing congenital cardiac abnormalities, short stature, and ovarian failure.
  • Key challenges include achieving normal adult height and initiating puberty.
  • Growth hormone (GH) therapy is a primary treatment modality.

Purpose of the Study:

  • To evaluate the efficacy of early growth hormone (GH) treatment in normalizing adult height for girls with Turner syndrome.
  • To assess the safety and impact of combining GH therapy with estrogen for puberty induction.
  • To investigate the long-term effects of GH on various physiological parameters.

Main Methods:

  • Analysis of studies using standard GH doses (approximately 4 IU/m(2)/day) in young girls (≤8 years).

Related Experiment Videos

  • Comparison of higher GH doses (6-8 IU/m(2)/day) and oxandrolone use.
  • Evaluation of early GH initiation combined with low-dose estrogens at age 12 for puberty induction.

    • Main Results:

    • Standard GH doses normalize adult height in most girls with Turner syndrome.
    • Early GH treatment does not interfere with puberty induction using low-dose estrogens.
    • GH therapy shows no adverse effects on body proportions, cardiac dimensions, blood pressure, metabolism, or bone density.

    Conclusions:

    • Early initiation of growth hormone (GH) treatment is effective in normalizing adult height for girls with Turner syndrome.
    • Combined GH and low-dose estrogen therapy for puberty induction is safe and does not compromise height outcomes.
    • GH treatment demonstrates a favorable safety profile regarding cardiovascular, metabolic, and skeletal health.