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Updated: Jan 24, 2026

Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry Methods for an Analysis of Human Pituitary Adenoma Tissue Proteome
Published on: April 2, 2018
Pituitary adenoma associated with gigantism and hyperprolactinemia
A Alikasifoglu1, N Kandemir, N Akalan
1Department of Pediatrics, Division of Pediatric Endocrinology, Hacettepe University, TR-06100 Ankara, Turkey. ayfer@gen.hun.edu.tr
Abstract:
An 11-year-old girl presented with excessive growth, headache, left visual loss and seizures. Her growth hormone (GH) and prolactin (PRL) levels were high and magnetic resonance imaging findings showed an invasive macroadenoma. Gross total tumor removal was performed and then radiotherapy and medical therapy were given. During the follow-up, she developed ACTH deficiency, secondary hypothyroidism and hypogonadism requiring replacement therapy. It is still unclear whether the biological characteristics of GH- and PRL-secreting tumors are different in children from those in adults. More data are needed before a definitive conclusion can be established.
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