Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Collagen and bone viscoelasticity: a dynamic mechanical analysis.

Junro Yamashita1, Xiaoe Li, Benjamin R Furman

  • 1Center for Clinical Bioengineering, The University of Texas Health Science Center, San Antonio, Texas 78284, USA.

Journal of Biomedical Materials Research
|January 12, 2002
PubMed
Summary

Bone's viscoelasticity is primarily influenced by moisture content, not collagen denaturation. Heating bone to 200°C denatured collagen, but this damage did not significantly alter its mechanical properties, especially when rehydrated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-sectional analysis of feline gut microbiota reveals differences across age-defined groups under varying environments.

Frontiers in veterinary science·2026
Same author

Conformity to stochastic invariance of microstructure influences mechanical competence of trabecular bone.

Bone·2026
Same author

Proteoglycan Dynamics and Bone Quality: Molecular Regulation to Age-Related Fragility.

Biomolecules·2026
Same author

Development of a core streptavidin-bridging amplified ELISA based on p54 epitope for high-sensitivity detection of african swine fever virus antibodies.

Veterinary journal (London, England : 1997)·2025
Same author

Correction: A non-invasive method for screening mitochondrial diabetes.

Frontiers in genetics·2025
Same author

A 3D generative structural model of trabecular bone using a novel probabilistic approach.

Journal of the mechanical behavior of biomedical materials·2025

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Materials Science

Background:

  • Bone's mechanical properties are crucial for skeletal function.
  • Type I collagen is the primary organic component of bone, influencing its viscoelasticity.
  • Understanding collagen's role in bone mechanics is vital for treating bone diseases and injuries.

Purpose of the Study:

  • To investigate the impact of Type I collagen denaturation on bone's viscoelastic properties.
  • To determine if collagen damage affects the loss factor (tan delta) and storage modulus (E') of bone.
  • To assess the influence of hydration on these thermally induced changes.

Main Methods:

  • Bone coupons were subjected to heat treatments (100°C or 200°C) to denature Type I collagen.

Related Experiment Videos

  • Specimens were tested in both dry and rehydrated states.
  • Dynamic mechanical analysis was used to measure viscoelastic properties (tan delta, E') across a range of temperatures.

    • Main Results:

    • Significant collagen denaturation occurred only at 200°C, regardless of hydration.
    • Collagen denaturation (DC%) did not significantly affect the loss factor (tan delta).
    • Wet bone specimens exhibited higher tan delta values than dry specimens, indicating moisture's prominent role.

    Conclusions:

    • Collagen denaturation has minimal impact on bone's viscoelasticity at a constant frequency.
    • Moisture content plays a significant role in determining bone's viscoelastic properties.
    • These findings suggest that hydration management may be key in understanding and treating bone conditions affecting mechanical integrity.