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Updated: Aug 9, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
HHV-8 infection: a model for reactivation and transmission
Lawrence Corey1, Scott Brodie, Meei-Li Huang
1Department of Medicine, Laboratory Medicine and Epidemiology, University of Washington, Seattle, WA, USA.
Abstract:
The rapid pace of knowledge about HHV-8 since its discovery has been one of the most exciting aspects of medical virology in the last decade. As outlined in this review, the discovery by Drs Chang and Moore of this virus has opened up a broad field of biology with interesting contrasts between current epidemiological data for Kaposi's sarcoma and the cell biology of this gamma herpesvirus. In particular, we summarise the paucity of virological data supporting genital sites of replication and emphasise detection of HHV-8 in the oropharynx. Hopefully continued study will address many of the critical questions that exist today regarding how this infection is transmitted and acquired.
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