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Estrogen attenuates postexercise HSP70 expression in skeletal muscle.
Zain Paroo1, Elizabeth S Dipchand, Earl G Noble
1Faculty of Health Sciences, School of Kinesiology, and Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 3K7.
American Journal of Physiology. Cell Physiology
|January 15, 2002
Summary
Exercise increases heat shock protein 70 (HSP70) in skeletal muscle, but this response is greater in males due to estrogen. Estrogen, not the estrogen receptor, mediates this sex-specific effect.
Area of Science:
- Exercise physiology
- Endocrinology
- Molecular biology
Background:
- Exercise induces heat shock protein 70 (HSP70) in skeletal muscle.
- The signaling pathways for this response often show sexual dimorphism.
Purpose of the Study:
- To investigate if HSP70 induction post-exercise is gender-specific.
- To identify the mechanisms behind any observed gender specificity.
Main Methods:
- Compared HSP70 protein and mRNA levels in male and female rats after exercise.
- Administered estrogen or placebo to ovariectomized rats before exercise.
- Tested non-estrogen receptor-binding estrogen analogs.
Main Results:
- Post-exercise HSP70 induction was significantly higher in male rats compared to females.
- Ovariectomized rats treated with estrogen showed a reduced HSP70 response to exercise.
- Estrogen-related compounds, without activating the estrogen receptor, also decreased HSP70 induction.
Conclusions:
- The gender-specific HSP70 response to exercise is mediated by estrogen.
- A non-genomic mechanism involving estrogen influences HSP70 induction.
- Sex hormones have physiological roles beyond reproduction.