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[Experimental study on anti-fatigue effect of shenfu injection on diaphragmatic muscle]
Objective:
To study the effect of Shenfu injection (SFI) on function of diaphragmatic muscle in rabbits.
Methods:
Taking the transdiaphragmatic pressure (Pdi), diaphragmatic electromyogram (EMGdi) and diaphragmatic evoked potential (DEP) as criteria for observation, the diaphragmatic fatigue (DiF) was induced by stimulating bilateral phrenic nerve for 30 minutes. Pdi, EMGdi and DEP induced by stimulation with different frequency (Fc) were recorded before and after treatment. Then the high/low (H/L) frequency ratio and central Fc were calculated and analysed by variance analysis and q test.
Results:
After administration of 2 ml/kg of SFI, the Pdi, H/L, Fc and amplitude of DEP were markedly increased and latent phase of DEP was shortened by the drug, in comparing with those before treatment, P < 0.05.
Conclusion:
SFI has the effect in antagonizing diaphragmatic fatigue.
