Related Experiment Videos
[Effect of emodin on fibroblasts in lupus nephritis]
1Department of Nephrology, Huizhou Central People's Hospital, Guangdong (516001).
Objective:
To observe the effects of emodin on human fibroblasts in culture of kidney in patients with lupus nephritis (LN).
Methods:
Fibroblasts were isolated from culture of kidney of LN patients, and the effect of emodin on 3H-TdR incorporated rate of fibroblasts was observed. The apoptosis and c-myc gene expression were detected in the same time by flow cytometry.
Results:
Emodin could inhibit the proliferation of fibroblasts, and promote the programmed cell death through upregulate c-myc gene expression in human renal fibroblasts.
Conclusion:
Emodin can inhibit proliferation and promote apoptosis of fibroblasts, which may be important in ameliorate interstitial fibrosis, thus improving prognosis of LN.