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Updated: Aug 1, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[High factor VIII as a risk factor for venous thrombosis]
K Elishkewitch1, S Berliner, A Eldor
1Department of Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty Medicine, Tel Aviv University, Tel Aviv.
Harefuah
|January 16, 2002
Summary
Elevated factor VIII levels are linked to thrombophilia, not an acute phase response. Measuring factor VIII is crucial for screening individuals with a history of blood clots.
Area of Science:
- Hematology
- Thrombosis Research
Context:
- Increased factor VIII concentrations are a known risk factor for thrombophilia.
- This elevation is attributed to genetic and environmental factors, not acute phase responses.
- Acquired Activated Protein C resistance may contribute to the thrombophilic pattern.
Purpose:
- To highlight the significance of factor VIII levels in thrombophilia.
- To emphasize the non-acute phase nature of elevated factor VIII.
- To advocate for the inclusion of factor VIII testing in thrombophilia screening.
Summary:
- Studies indicate a strong association between high factor VIII concentrations and thrombophilia.
- Elevated factor VIII is due to genetic and environmental influences, independent of acute phase reactions.
- Venous thromboembolism recurrence is high in patients with elevated factor VIII, suggesting its importance in screening.
Impact:
- Determining factor VIII concentrations should be a standard part of laboratory thrombophilia screening.
- This testing can help identify individuals at higher risk for recurrent venous thromboembolism.
- Understanding the causes of elevated factor VIII aids in personalized risk assessment and management.
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