Related Experiment Video
Updated: Sep 21, 2026

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions
Published on: July 15, 2013
[Cytostatic drug extravasation--are there new recommendations for therapeutic management?]
1Medizinische Klinik IV, Schwerpunkt Hämatologie/Onkologie, Klinikum der Justus-Liebig-Universität, Klinikstrasse 36, D-35385 Giessen, Deutschland. klaus.fenchel@innere.med.uni-giessen.de
Abstract:
Extravasations are a matter of concern in cytostatic treatment. They may range from patients' discomfort up to severe complications such as necrosis and amputation. Cytotoxic drugs in general differ in a broad variety in their ability to induce severe cutaneous reactions and therefore the possible counter-measures vary. Though the compliance with regulations concerning the application and injection or infusion of cytotoxic substances can minimize the risk of inducing an extravasation, these basic safety procedures are reflected beside an overview of the literature concerning specific antidotes and procedures.
More Related Videos
Related Concept Videos
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Pharmacokinetics in Pediatric Patients: Drug Excretion
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Modified-Release Drug Delivery Systems: Site-Targeted

