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Related Experiment Videos

[Central hyperacusis with phonophobia in multiple sclerosis].

K Pfadenhauer1, H Weber, A Rösler

  • 1Klinikum Augsburg, Neurologische Klinik mit klinischer Neurophysiologie, Stenglinstrasse 2, 86156 Augsburg.

Der Nervenarzt
|January 16, 2002
PubMed
Summary

Central phonophobia, a rare auditory disturbance in multiple sclerosis (MS), can manifest as painful sound perception. Lesions in the central auditory pathway and pons cause these symptoms, often preceding MS diagnosis.

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Area of Science:

  • Neurology
  • Otolaryngology
  • Neuroscience

Background:

  • Auditory disturbances are common in multiple sclerosis (MS).
  • Central auditory pathway lesions can cause hearing loss despite normal auditory testing.
  • Central phonophobia, characterized by unpleasant and painful sound perception, is rarely described in MS.

Observation:

  • Three patients presented with central phonophobia as their initial symptom.
  • Symptoms included pain triggered by specific sounds, intolerance to nonverbal noise, and auditory processing issues like echo and localization difficulties.
  • Clinical examination revealed brainstem syndrome signs, but standard auditory tests were normal.

Findings:

  • Pathological acoustic evoked potentials (AEP) with prolonged latency III-V were observed in all patients.

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  • Lesions were identified in the pons and central auditory pathway.
  • Possible causes include lateral spread between the lateral lemniscus and trigeminal pathway or central sensory modulation dysfunction.

    • Implications:

    • Central phonophobia can be an early indicator of multiple sclerosis.
    • Understanding these auditory pathway dysfunctions is crucial for early MS diagnosis and management.
    • This highlights the complex neurological underpinnings of auditory symptoms in MS.