Related Experiment Videos
Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15
M Okamoto1, N Yokoi, T Serikawa
1The Institute of Experimental Animal Sciences, Osaka University Medical School, Suita, Japan.
The Journal of Veterinary Medical Science
|January 16, 2002
Abstract:
ICGN is a partially inbred strain of mice with nephrotic syndrome caused by spontaneous glomerular lesion. It has been reported that the albuminuria in ICGN mouse was controlled by at least a single autosomal recessive gene (nep). In this study, we mapped the nep locus by linkage analysis of backcross progeny between ICGN and MSM mice using DNA pooling method. The linkage analysis revealed that the nep locus was localized on the distal part of chromosome 15.