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Updated: Aug 10, 2026
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Published on: May 18, 2018
Merkel cell carcinoma: an overview and case report
B Woodworth1, J P Lacey, R G Amedee
1Tulane University School of Medicine, New Orleans, Louisiana, USA.
Summary
Merkel cell carcinoma is a rare, aggressive skin cancer primarily affecting fair-skinned individuals over 60. It frequently recurs and metastasizes, especially on sun-exposed skin like the head and neck.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Merkel cell carcinoma (MCC) is an exceptionally rare neuroendocrine skin cancer.
- It is characterized by a high propensity for recurrence and metastasis.
- MCC predominantly affects individuals of white ethnicity, typically in their sixth and seventh decades of life.
Observation:
- Lesions commonly appear on sun-exposed skin areas.
- The head and neck region, particularly the cheeks and eyelids, are frequent sites for MCC development.
- This aggressive tumor presents unique clinical and histological features.
Findings:
- The article details the known etiology and pathogenesis of Merkel cell carcinoma.
- It reviews current treatment strategies for this rare neoplasm.
- Understanding the tumor's behavior is crucial for effective management.
Implications:
- Early diagnosis and prompt treatment are vital due to MCC's aggressive nature.
- Further research into MCC's etiology and pathogenesis may reveal novel therapeutic targets.
- Improved understanding can lead to better patient outcomes for this rare skin cancer.
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