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EGF receptor signalling: roles of star and rhomboid revealed
1Institut für Neuro- und Verhaltensbiologie, Universität Münster, 48149, Münster, Germany.
Current Biology : CB
|January 16, 2002
Abstract:
Recent studies have clarified how the active form of the Drosophila EGF receptor ligand Spitz is produced: Star chaperones Spitz in the ER and mediates its transport to the Golgi, where the intramembrane serine protease Rhomboid cleaves the Spitz proprotein to initiate secretion.