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A closer look at proteolysis and MHC-class-II-restricted antigen presentation
Ana-Maria Lennon-Duménil1, Arnold H Bakker, Paula Wolf-Bryant
1Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Current Opinion in Immunology
|January 16, 2002
Abstract:
Antigen presentation by MHC class II molecules relies on the action of endocytic proteases, which are differentially expressed in antigen-presenting cells and are regulated by different components of the immune system. Endocytic enzymes process and convert exogenous antigens into peptidic determinants capable of interaction with MHC class II molecules. Chemical and genetic tools have recently been developed to study the role of lysosomal proteases in antigen presentation.