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TGF-beta signaling: positive and negative effects on tumorigenesis
Lalage M Wakefield1, Anita B Roberts
1Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 41, Room C629, 41 Library Drive, MSC 5055, Bethesda, Maryland 20892-5055, USA. Wakefiel@dce41.nci.nih.gov
Current Opinion in Genetics & Development
|January 16, 2002
Abstract:
TGF-beta binding to the cell surface triggers activation of multiple signal transduction pathways that are connected in intricate ways with each other, and with other response networks involved in sensing cellular information input. Recent data indicate that changes in signal intensity and connectivity of these pathways may underlie the complex transition of the TGF-beta pathway from tumor suppressor to oncogene during tumorigenesis.