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Related Experiment Videos

Apoptosis and tumourigenesis.

John A Hickman1

  • 1Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, Paris, France. john.hickman@fr.netgrs.com

Current Opinion in Genetics & Development
|January 16, 2002
PubMed
Summary
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Knowing your tumour?

The Lancet. Oncology·2020

Tumor cells evade programmed cell death (apoptosis) by losing DNA damage sensors and increasing survival signals. This evasion is crucial for tumor growth and maintenance, often driven by single oncogenes.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Death Research

Background:

  • Tumorigenesis involves the evasion of apoptosis, a critical process for eliminating damaged cells.
  • Key molecules sensing DNA damage or initiating cell death are often dysfunctional in tumors.
  • Cancer cells frequently enhance survival pathways to resist cell death.

Purpose of the Study:

  • To investigate the role of apoptosis evasion in tumor formation and maintenance.
  • To understand how DNA damage sensing and cell death pathways are compromised during tumorigenesis.
  • To explore the potential of targeting survival signals for cancer therapy.

Main Methods:

  • Analysis of DNA damage response pathways in tumor cells.
  • Investigating the expression and function of apoptosis regulators like Bax and Bak.

Related Experiment Videos

  • Studying the impact of oncogenes, such as BCR-ABL, on cell survival and apoptosis.

    • Main Results:

    • Apoptosis initiation by DNA damage critically depends on Bax or Bak expression.
    • Single oncogenes, like BCR-ABL, can provide sufficient survival signals to maintain the oncogenic state.
    • Suppression of oncogenes can induce apoptosis and lead to tumor regression in vivo.

    Conclusions:

    • Evasion of apoptosis is a fundamental mechanism in tumorigenesis.
    • Targeting oncogene-driven survival pathways offers a potential strategy for cancer treatment.
    • The concept of single oncogene-mediated tumor maintenance through apoptosis inhibition is significant.