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Recent developments in combinatorial organic synthesis
1Department of Chemistry, University of Southampton, Southampton, UK SO17 1BJ. ganesan@soton.ac.uk
Drug Discovery Today
|January 16, 2002
Abstract:
The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.