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Related Experiment Videos

Enzymatically cleavable linker groups in polymer-supported synthesis.

Reinhard Reents1, Duraiswamy A Jeyaraj, Herbert Waldmann

  • 1Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany.

Drug Discovery Today
|January 16, 2002
PubMed
Summary

Researchers developed enzymatically cleavable linker groups for efficient molecule synthesis on solid supports. These linkers enable mild release of target compounds, advancing combinatorial chemistry applications.

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Area of Science:

  • Organic Chemistry
  • Biochemistry
  • Materials Science

Background:

  • Combinatorial chemistry aims for broadly applicable linker groups.
  • Linker stability under various reaction conditions is crucial.
  • Mild release of target compounds from polymeric supports is a key goal.

Purpose of the Study:

  • To summarize the development of enzymatically cleavable linker groups.
  • To highlight their application in preparing diverse target molecules on polymeric supports.

Main Methods:

  • Development of novel linker chemistries.
  • Solid-phase synthesis techniques.
  • Enzymatic cleavage assays.

Main Results:

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  • Successful synthesis of various target molecules using the developed linkers.
  • Demonstration of linker stability under diverse reaction conditions.
  • Efficient and mild release of compounds facilitated by enzymatic cleavage.

    • Conclusions:

    • Enzymatically cleavable linkers offer a versatile solution for solid-phase synthesis.
    • These linkers meet the demand for stability and mild release conditions.
    • Advancements in linker technology significantly benefit combinatorial chemistry.