Multi-component reactions and evolutionary chemistry
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Updated: Aug 10, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
1Morphochem, Gmunderstr. 37, D-81379 München, Germany. lutz.weber@morphchem.de
Abstract:
Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.
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