Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rex-centric mutualism.

Roderick A Slavcev1, Sidney Hayes

  • 1Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.

Journal of Bacteriology
|January 16, 2002
PubMed
Summary

The lambda prophage Rex system offers host protection by inducing arrested growth, despite some cell-killing effects. This bacteriophage system demonstrates a dual role in bacterial defense.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential Vaccine or Antimicrobial Reagents: Simple Systems for Producing Lambda Display Particles (LDP) and Sheathed Lambda DNA Vaccine Particles (LDNAP).

Viruses·2025
Same author

Ministring DNA (msDNA): a novel linear covalently-closed DNA with enhanced stability for gene and cell therapy applications.

Scientific reports·2025
Same author

Advancing ocular gene therapy: a machine learning approach to enhance delivery, uptake and gene expression.

Drug discovery today·2025
Same author

Manufacturing DNA in <i>E. coli</i> yields higher-fidelity DNA than <i>in vitro</i> enzymatic synthesis.

Molecular therapy. Methods & clinical development·2024
Same author

Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer.

Microbial cell factories·2023
Same author

A snapshot of the λ T4rII exclusion (Rex) phenotype in Escherichia coli.

Current genetics·2021

Area of Science:

  • Bacteriology
  • Molecular Biology
  • Genetics

Background:

  • Bacteriophages, viruses that infect bacteria, play crucial roles in microbial ecosystems.
  • Lysogenic bacteriophages integrate their genetic material into the host genome.
  • The lambda phage Rex system's function in host cell fate remains incompletely understood.

Purpose of the Study:

  • To investigate the phenotype conferred by the Rex exclusion system of lambda prophage.
  • To determine if Rex mediates host protection or cell killing.

Main Methods:

  • Utilized genetic analysis of the lambda prophage Rex system.
  • Observed the effects of Rex expression on lysogenic bacterial host cells.

Main Results:

  • The Rex system was found to induce an arrested growth phase in lysogenic cells.
  • This arrested growth confers an overall protective ability to the host.
  • The protective mechanism is associated with a degree of cell killing.

Conclusions:

  • The lambda prophage Rex system exhibits a dual phenotype, providing host protection through growth arrest.
  • The Rex system balances host survival benefits against some cell-killing consequences.
  • Understanding the Rex system's role is vital for bacteriophage-host interaction studies.

Related Experiment Videos