Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cryoglobulinemia vasculitis.

Patrice Cacoub1, Nathalie Costedoat-Chalumeau, Olivier Lidove

  • 1Service de Médecine Interne, Hôpital La Pitié-Salpêtrière, Paris, France. patrice.cacoub@psl.ap-hop-paris.fr

Current Opinion in Rheumatology
|January 16, 2002
PubMed
Summary

Mixed cryoglobulinemia, a vasculitis often linked to Hepatitis C virus infection, involves immune complexes causing purpura, joint pain, and fatigue. This review explores the connection between Hepatitis C virus and mixed cryoglobulinemia, including liver disease and treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High thrombin activity associated with crohn's disease induces microbiota pathogenicity contributing to mucosal inflammation.

Gut microbes·2026
Same author

Subtype-specific mortality in idiopathic inflammatory myopathies: A hospital-based cohort.

Autoimmunity reviews·2026
Same author

Fecal microbiota transplantation in compassionate indications: French experience from 2019 to 2022.

Infectious diseases now·2026
Same author

Impact of ANCA specificity on risk of cardiovascular events and death in ANCA-associated vasculitis.

RMD open·2026
Same author

Safety and efficacy of REP 2139-Mg in patients with HDV-related advanced liver disease in an international compassionate access program.

Journal of hepatology·2025
Same author

Towards a minimal core dataset for systemic lupus erythematosus studies.

Lupus science & medicine·2025

Area of Science:

  • Immunology
  • Rheumatology
  • Hepatology

Background:

  • Cryoglobulins are serum immunoglobulins that precipitate in cold and redissolve upon warming.
  • Mixed cryoglobulinemia involves immune complex vasculitis, often associated with connective tissue diseases, hematologic malignancies, or infections.
  • This condition presents with purpura, arthralgia, and asthenia, potentially affecting organs like the kidneys and peripheral nervous system.

Purpose of the Study:

  • To review the pathogenesis of mixed cryoglobulinemia, particularly its association with Hepatitis C virus (HCV) infection.
  • To analyze the role of liver alterations in HCV-associated mixed cryoglobulinemia.
  • To identify predictive factors for cryoglobulin production in HCV patients and discuss treatment strategies for associated vasculitis.

Main Methods:

Related Experiment Videos

  • Literature review of published data on HCV-mixed cryoglobulinemia.
  • Analysis of the relationship between liver disease and cryoglobulin production.
  • Examination of factors influencing cryoglobulin formation and vasculitis in HCV patients.

Main Results:

  • HCV infection is a major cause of mixed cryoglobulinemia vasculitis.
  • Liver disease is frequently observed in patients with mixed cryoglobulinemia.
  • Specific predictive factors for cryoglobulin production in HCV patients have been identified.

Conclusions:

  • HCV-mixed cryoglobulinemia is a significant clinical entity, often a manifestation of chronic hepatitis.
  • Understanding the link between HCV, liver disease, and cryoglobulinemia is crucial for patient management.
  • Targeting HCV and managing vasculitis are key therapeutic approaches.