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Recurrent purpura fulminans associated with drug-resistant Streptococcus pneumoniae infection in an asplenic girl.

Chitsanu Pancharoen1, Pantipa Chatchatee, Jarungchit Ngamphaiboon

  • 1Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. chitsanu.p@chula.ac.th

The Pediatric Infectious Disease Journal
|January 16, 2002
PubMed
Summary

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A rare case of purpura fulminans caused by drug-resistant Streptococcus pneumoniae was successfully treated with ceftriaxone. The patient was found to be asplenic, meaning they lacked a spleen.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Critical Care Medicine

Background:

  • Purpura fulminans is a rare, life-threatening condition characterized by disseminated intravascular coagulation and skin necrosis.
  • Streptococcus pneumoniae is a common pathogen, but drug resistance poses a significant therapeutic challenge.
  • Asplenic individuals are at increased risk for severe infections, particularly from encapsulated bacteria like Streptococcus pneumoniae.

Observation:

  • A patient presented with purpura fulminans.
  • The condition was associated with drug-resistant Streptococcus pneumoniae infection.
  • Diagnostic imaging, including ultrasonography and splenic scan, confirmed the absence of a spleen (asplenia).

Findings:

  • Ceftriaxone therapy demonstrated efficacy in treating the purpura fulminans.

Related Experiment Videos

  • The successful response to ceftriaxone highlights its potential role in managing severe pneumococcal infections.
  • The case underscores the importance of identifying asplenia in patients with severe infections.

    • Implications:

    • This case provides valuable clinical insight into managing purpura fulminans in asplenic patients with drug-resistant Streptococcus pneumoniae.
    • It supports the use of ceftriaxone in such critical scenarios.
    • Further research may explore optimal antibiotic strategies for asplenic individuals with severe bacterial infections.