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Protective effect of ajoene on acetaminophen-induced hepatic injury in mice
A Hattori1, N Yamada, T Nishikawa
1Biodevelopment Division, Central Institute, Nagoya Seiraku Co. Ltd., Aichi, Japan.
Abstract:
Ajoene, a garlic-derived sulfur-containing compound, exhibited a hepatoprotective effect against acetaminophen-induced liver injury in mice. A pretreatment with ajoene suppressed the rise in serum glutamic-pyruvic transaminase activity and the reduction in the hepatic reduced glutathione level. These effects of ajoene were observed dose-dependently (20-100 mg/kg). The pretreatment by ajoene also suppressed the decrease in hepatic protein thiol content resulting from acetaminophen administration.