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Related Experiment Videos

Is the chronically denervated kidney supersensitive to catecholamines?

Rohit Ramchandra1, Carolyn J Barrett, Sarah-Jane Guild

  • 1Circulatory Control Laboratory, Department of Physiology, University of Auckland Medical School, Private Bag 92019, Auckland, New Zealand.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|January 17, 2002
PubMed
Summary

Chronic kidney denervation does not cause increased responsiveness to phenylephrine. This validates the unilateral denervated kidney model for studying renal sympathetic nerve function in regulating kidney function.

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Area of Science:

  • Physiology
  • Nephrology
  • Renal Denervation

Background:

  • The unilateral denervated kidney model is used to study renal sympathetic nerve function.
  • Concerns exist regarding potential supersensitivity in chronically denervated kidneys.
  • This supersensitivity could confound studies on renal nerve effects.

Purpose of the Study:

  • To investigate if chronic kidney denervation leads to increased renal responsiveness to phenylephrine.
  • To compare responses in chronically denervated, acutely denervated, and intact kidneys.
  • To assess this in both normal and angiotensin II-induced hypertensive rabbits.

Main Methods:

  • Utilized the rabbit unilateral denervated kidney model.
  • Administered phenylephrine to assess acute renal blood flow responses.

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  • Compared responses across chronically denervated, acutely denervated, and intact kidneys.
  • Included rabbits with chronic hypertension induced by angiotensin II infusion.

    • Main Results:

    • Chronic denervation did not increase renal responsiveness to phenylephrine compared to intact or acutely denervated kidneys.
    • No significant difference in phenylephrine response was observed in hypertensive rabbits.
    • Findings suggest supersensitivity is not a confounding factor in this model.

    Conclusions:

    • The unilateral denervated kidney model is a valid approach for studying renal sympathetic nerve function.
    • Observed differences in renal function between nerve-intact and denervated kidneys are unlikely due to supersensitivity.
    • This model reliably allows for the investigation of renal nerve regulation of kidney function.