Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular involvement in myelodysplastic syndromes.

R Bogdanović1, M Kuzmanović, J Marković-Lipkovski

  • 1Institute of Mother and Child Health of Serbia, 8 R. Dakica St., 11070 Belgrade, Yugoslavia. Maloun@eunet.yu

Pediatric Nephrology (Berlin, Germany)
|January 17, 2002
PubMed
Summary

This study highlights myelodysplastic syndromes (MDS) as a cause of steroid-responsive nephrotic syndrome (NS) in children, a rare but important association. Early detection and treatment are crucial for managing these pediatric kidney and blood disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to the letter: 'multimodality imaging in cardio-oncology: from detection to actionable management to the editor'.

European heart journal. Cardiovascular Imaging·2026
Same author

Hydrogen isotopes retention studies using laser and microwave induced plasma coupling.

Scientific reports·2025
Same author

SHORT HISTORY OF OBESITY.

Acta endocrinologica (Bucharest, Romania : 2005)·2025
Same author

Novel telomerase reverse transcriptase gene mutation in a family with aplastic anaemia.

Familial cancer·2024
Same author

EACVI survey on radiation exposure in interventional echocardiography.

European heart journal. Cardiovascular Imaging·2024
Same author

Expanding the Phenotypic Spectrum: Chronic Kidney Disease in a Patient with Combined Oxidative Phosphorylation Defect 21.

Balkan journal of medical genetics : BJMG·2024

Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Oncology

Background:

  • Glomerular diseases are documented in adults with myelodysplastic syndromes (MDS).
  • Similar reports in pediatric patients are scarce, necessitating further investigation into this association.
  • Myelodysplastic syndromes represent a group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and a high risk of transformation to acute myeloid leukemia.

Observation:

  • Two pediatric cases of myelodysplastic syndromes-associated steroid-responsive nephrotic syndrome (NS) are presented.
  • Patient 1 exhibited MDS with myelofibrosis, presenting with pancytopenia and nephrotic syndrome, responsive to high-dose steroids but with persistent hematologic issues.
  • Patient 2 had refractory anemia with monosomy 19, experiencing nephrotic syndrome and hematologic relapse responsive to corticosteroids, indicating a potential link between MDS and NS.

Related Experiment Videos

Findings:

  • Renal biopsy findings in both pediatric patients were consistent with idiopathic nephrotic syndrome.
  • A literature review identified 16 adult cases of glomerulopathy associated with MDS, manifesting as NS, renal insufficiency, and various glomerulonephritis types.
  • The study suggests that myelodysplastic syndromes can be associated with corticosteroid-responsive nephrotic syndrome in children, expanding the known spectrum of MDS complications.

Implications:

  • Pediatricians and hematologists should consider searching for glomerular disease in children diagnosed with myelodysplastic syndromes.
  • MDS should be recognized as a potential underlying cause of nephrotic syndrome in pediatric patients, particularly those with steroid-responsive disease.
  • This finding contributes to understanding the extraskeletal manifestations of myelodysplastic syndromes and informs diagnostic and therapeutic strategies in affected children.