A pedigree partitioning approach to quantitative trait loci mapping of IgE serum level in the GAW12 Hutterite data

V S Pankratz1, S J Iturria

  • 1Section of Biostatistics, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.

Genetic Epidemiology
|January 17, 2002
PubMed

Related Concept Videos

Pedigree Analysis02:21

Pedigree Analysis

A pedigree is a diagram displaying a family’s history of a trait. Analyzing pedigrees can reveal (1) whether a trait is dominant or recessive, (2) the type of chromosome, autosomal or sex, a trait is linked to, (3) genotypes of family members, and (4) probabilities of phenotypes in future generations. For families with a history of autosomal or sex-linked diseases, this information can be crucial to family planning.Pedigrees Display Family HistoriesIn various plant and animal species,...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Punnett Squares01:53

Punnett Squares

A Punnett square displays the possible genotypes offspring can inherit from two parental genotypes. If a trait’s inheritance pattern (e.g., dominant or recessive) is known, Punnett squares can also be used to determine the probability of inheriting a phenotype. Punnett squares are applicable in situations where trait inheritance is determined by a single gene locus and traits are independently inherited. However, they cannot predict trait probabilities for more complex genetic inheritance...
Dihybrid Crosses01:22

Dihybrid Crosses

To determine whether traits are inherited together or separately, Gregor Mendel crossed pea plants that differed in two traits. These parental plants were homozygous for both traits but displayed different phenotypes. The first generation of offspring were all dihybrids, heterozygotes exhibiting the two dominant phenotypes. When self-fertilized, the dihybrids consistently produced progeny with a 9:3:3:1 ratio of four possible phenotype combinations. This ratio suggested that inheriting one...
Multiple Allele Traits02:19

Multiple Allele Traits

For the same gene multiple alleles can interact to influence phenotypes like the shape and protein composition of an individual cells.By studying allele interactions on the molecular and cellular levels researchers can understand the resulting phenotypes and complications of human conditions like sickle cell trait, improving treatment.The ABO blood group system is a common example of multiple alleles in humans. This system includes three alleles called IA, IB, and i alleles, which combine in...