Related Experiment Video
Updated: Aug 17, 2026
Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography
Published on: January 18, 2020
Comparison of the QTDT analysis for IgE in the CSGA data set
G P Page1, M A Wilcox, J Occhiuto
1Department of Biometry and Epidemiology, Medical University of South Carolina, 135 Rutledge Avenue, Suite 1148, Charleston, SC 29524, USA.
Abstract:
Over the past few years at least 13 transmission/disequilibrium test (TDT)-based tests have been developed for quantitative (Q) traits for the assessment of association or linkage in the presence of the other. A total of six of these QTDT methods were used to analyze log10IgE in the Collaborative Study on the Genetics of Asthma data set. Only moderate agreement was found between the tests. The results of the QTDT analyses were only slightly affected by the use of gender and age as covariates. Results from analysis of IgE and log10IgE were inconsistent. Our conclusion is that there is only modest agreement among the QTDT methods examined, covariates should be used even if they have a small effect, and that data should be normalized before analysis.
