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Updated: Aug 14, 2026

Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 25, 2010
Association analysis in a variance components framework
G R Abecasis1, L R Cardon, W O Cookson
1Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Abstract:
Association analyses conducted in a variance components framework can include information from all available individuals but remain unbiased in the presence of familiality or linkage. Models that include both linkage and association parameters provide different estimates of the effect of a single locus and can be used to distinguish causal polymorphisms from other types of variation. We examine some of these models and their properties in a blind analysis of the simulated Genetic Analysis Workshop 12 data sets.
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