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Incorporating age at onset information into the transmission/disequilibrium test
L Hsu1, R L Prentice, L P Zhao
1Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., N., MP-665, Seattle, WA 98109-1024, USA.
Genetic Epidemiology
|January 17, 2002
Abstract:
In this paper, we proposed two approaches for incorporating the age at onset into the transmission/disequilibrium test (TDT). Trios (affected offspring and their parents) were extracted from the first four replicate data sets of the general population type. Focusing on chromosome 6 where MG6 and MG7 reside, we compared the usual TDT with the newly proposed tests in terms of gene localization.